The game is apparently considered a complete remake of the original, it will include expanded gameplay, more playable characters, more story levels, new enemies, bosses and over 110 new items.
The Binding of Isaac: Rebirth‘s official features include:
Local co-op play
Competitive load-outs: Players can do the same run for Twitch streams, etc.
50 percent of new content over the original game
Steam loyalty discount for players who already own the original game
Over two playable characters
Tons of new challenge runs and more secret stuff
The Binding of Issac: Rebirth will be coming early 2014 for PS4, PS Vita, and Steam.
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